Step 1. Damage to endothelial function of arteriosclerosis, hyperlipidemia, hypertension, carbon monoxide, inflammatory mediators, LDL, etc., cause damage to endothelial cells and dysfunction. The accumulated geoprotein is oxidized by an endothelial cell, which increases the expression of the adherents necessary to attach mononucleus in the blood and move to the endothelial tissue to allow mononucleus to flow in. In addition, various cytokines are secreted to reduce vasodilating capacity.
Source: Diabetes Treatment Standard:: Health Common Sense – Save Narrowing Blood Vessels! How to Prevent Takegami Arteriosclerosis? (tistory.com )
Step 2. Mononuclear cells that flow into the inflammatory cell-moving inner membrane promote the inflow of mononuclear cells by stimulating LDL oxidized by differentiation into macrophages, and secrete oxidizing substances, cytokines, and coagulants to form foam cells.
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출처 : Macrophages (foamed cells) filled with extracellular cholesterol and cholesterol are accumulated in the subendothelial space. LDL Subsequent Structural Changes – ppt Download (slideplayer.com )
Step 3. Fat accumulation and smooth muscle cell proliferation mononuclear cells turn into foam cells, and simultaneously secrete growth factors to increase smooth muscle cells and connective tissue cells, resulting in thickening of arterial walls. As the arterial wall thickens and the arterial lining also expands, platelets in the blood stick to the inner wall to secrete growth factors and form plugs to form a fibrous cap.
Macrophages (foamed cells) filled with extracellular cholesterol and cholesterol are accumulated in the subendothelial space. LDL Subsequent Structural Changes – ppt Download (slideplayer.com )
Step 4. The arterial lumen is noticeably damaged by the bamboo spot structure forming plug. Cracks occur in the plug wall, rupture, and blood clots are formed, and substances inside the plug are exposed to the blood, resulting in platelet adsorption and blood clotting reactions, resulting in blood clots, and the inside diameter of the artery quickly narrows. Blood vessels contract due to vasoconstrictor factors advantageous to platelets, and stenosis worsens, resulting in bamboo arteriosclerosis and thrombosis.
출처 : 한국지질·동맥경화학회. Korean Society for Hyperlipidemia and atherosclerosis
출처 : 한국지질·동맥경화학회. Korean Society for Hyperlipidemia and atherosclerosis
